The concept of green development has been upgraded to a new strategic level in China. The discussion of influencing factors of green development and analysis of regional differences will provide reference for the government to formulate relevant policies. Based on the connotation of green development, this paper constructs the evaluation index system of regional green development and calculates the provincial green development of China from 2006 to 2014. It also constructs a spatial Durbin model to discuss the impact of technological innovation, structural change and environmental regulation on the regional green development. The results show that technological innovation can promote the green development with a spatial spillover effect. In particular, technological innovation plays a more significant role in the eastern region. FDI only contributes significantly and shows spillover effect to the green development in the eastern region. The increase of the industrial proportion in the central region not only has a significant restraining effect on the green development in that region, but also seriously affects the green development in other regions. The stricter environmental regulation only promotes the green development in the eastern region.