Integrating innovation, coordination, greenness, openness and sharing as a complex system of regional development, this paper employs the method of fuzzy comprehensive evaluation, system coordination and cluster analysis to evaluate the status of regional development in Henan province. Main conclusions of this study include: 1)The overall level of regional development in Henan province is low, with Zhengzhou being the spacial center of a core-periphery structure. Huge regional differences in innovation and openness curbs the sustainable and coordinated regional development. There is strong correlation between five subsystems of development and regional economic characteristics. 2)Henan Province as a whole shows a weak coordinated development, with most of the cities having a low level of coordination in their regional development. The correlation between coordination and regional economic indicators is weak while the supportive effect of economic development on regional coordination does not come into play.3)Five major systematic strategies of coordinated development are proposed with pertinence to different regional characteristics.