Abstract The development of the airport-based airport economy is an important way to promote industrial and technological upgrading, achieve regional coordination and high-quality development. The article takes the airport economy by sub-hub airport type and sub-regional distribution as the research object, using the data of 37 “million-level” airports and their regions in China from 2013 to 2017, and empirically analyzes the influencing factors of the airport economic development and the impact of economic development on the region. The empirical results show that the airport economy dominated by the airport industry is the “growth pole” of the regional economy. Its growth effect can significantly drive the rise and development of the entire regional economy. Factors such as budget expenditure are positively correlated. Therefore, various regions should strengthen the strategic position of the airport economy, construct the airport industry system according to local conditions, train and introduce professional talents and other related measures to promote the rapid development of the airport economy.