Abstract Based on the reality of the increasing degree of market integration in China, this paper aims to clarify whether the improvement of market integration can lead to the effective allocation of resources, and then affect the adjustment of industrial structure. On the basis of using price index to measure the degree of inter-regional market integration in China, this paper selects the panel data of 30 provinces of China from 2000 to 2018, and uses spatial econometric estimation to empirically test the relationship among market integration, effective resource allocation and industrial structure adjustment. The results show that the industrial production activities among regions in China are not random and independent, and will be affected by the industrial development of other regions. And there is a significant spatial correlation between regional industrial structures, and the spatial correlation mainly comes from the transmission of spatial error terms. The market integration of the whole, eastern and central regions can significantly promote the efficiency of resource allocation, and the effect of optimal allocation of resources has a significant positive impact on the development of China's industrial structure. The efficiency of resource allocation plays an intermediary effect in the process of market integration affecting industrial structure adjustment, but this effect is not significant in the western region.