Based on the questionnaire of 500 new enterprises, this study explores how entrepreneurial learning affect the novelty-centered business model design, and how to better promote this design by adopting different modes of entrepreneurial learning under different market uncertainty environments. The results show that experiential learning and acquisitive learning both have positive effects on novelty-centered business model design. Acquisitive learning has a more important effect on novelty-centered business model design than experiential learning under highly competitive environment. There is a complementary relationship between the two types of learning.